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Tirzepatide is an FDA-approved prescription medication marketed as Mounjaro for type 2 diabetes mellitus and Zepbound for chronic weight management in adults with BMI 30 kg/m, or 27 kg/m with at least one weight-related comorbidity

These effects were achieved under reduced activation of noncanonical signaling pathways including receptor internalization and -arrestin recruitment, an initially surprising observation as these have previously been linked to increased GLP-1R responses when measured acutely 10,14,36

Examples include warfarin, methotrexate, and allopurinol

Solution: Be patient, give it at least a few weeks to a month before expecting noticeable improvements